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Table 1 Cytosolic and nuclear FKBP51 protein and FKBP51 mRNA in cells of patients treated with F/ICS and F/ICS/Th for 4 weeks.

From: Increased FKBP51 in induced sputum cells of chronic obstructive pulmonary disease patients after therapy

   

F/ICS

F/ICS/Th

FKBP51

Protein

Cytosol (C)

100.0 ± 18.1

157.6 ± 21.4**

  

Nuclei (N)

61.0 ± 11.9

79.5 ± 14.7*

  

Ratio (C/N)

1.64 ± 0.36

1.98 ± 0.38**

 

mRNA

100.0 ± 46.8

132.7 ± 51.1

 
  1. Relative content of cytosolic and nuclear FKBP51 protein and FKBP51 mRNA in cells isolated from induced sputum of stable COPD patients treated with formoterol + budesonide (F/ICS; n = 18) and formoterol + budesonide + theophylline (F/ICS/Th; n = 18) b.i.d. for 4 wk. Expressions of FKBP51 were equalized in each sample for loading and numerized with density software. The mean FKBP51 expression in cytosolic fraction of cells isolated from F/ICS-treated patients was set as 100 relative units. *P < 0.05 compared with the F/ICS-treated group; **P < 0.01 compared with the F/ICS-treated group.
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European Journal of Medical Research

ISSN: 2047-783X

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