Association of CYP1A1, GSTM1 and GSTT1 gene polymorphisms with risk of non-small cell lung cancer in Andhra Pradesh region of South India

Table 11 Association of Lipid peroxidation (MDA) levels in relation to CYP1A1 and GST gene polymorphisms in NSCLC patients and healthy controls

Gene	Genotype	Lung cancer patients (MDA levels)		p value	Controls (MDA levels)		p value	Total p value
Gene	Genotype	n	Mean ± SE	p value	n	Mean ± SE	p value	Total p value
CYP1A1 m1	T/T	127	4.18 ± 0.24		138	1.72 ± 0.10		0.01*
	T/C	90	4.21 ± 0.13	<0.01*	98	1.79 ± 0.24	0.42	<0.01*
	C/C	29	4.30 ± 0.13	<0.01*	14	2.00 ± 0.42	0.83	<0.01*
CYP1A1 m2	A/A	73	4.23 ± 0.15		196	1.56 ± 0.11		0.07
	A/G	162	4.22 ± 0.11	0.39	34	1.75 ± 0.23	0.34	0.79
	G/G	11	4.52 ± 0.39	0.87	20	2.12 ± 0.28	0.29	0.86
GSTM1	+/+	182	4.11 ± 0.10		187	1.73 ± 0.03		<0.01*
	–/–	64	4.60 ± 0.13	0.02*	63	1.95 ± 0.71	0.21	<0.001*
GSTT1	+/+	200	4.06 ± 0.09		224	1.75 ± 0.29		<0.001*
	–/–	46	5.00 ± 0.20	0.31	26	1.91 ± 0.12	0.09	<0.01*

ISSN: 2047-783X