Possible factors (reference) | Multivariate analyses in all agesb | Multivariate analyses in younger patients (<65 years)b | Multivariate analyses in older patients (≥65 years)b | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Total study population | AE groupc | Total study population | AE groupc | Total study population | AE groupc | |||||||
N = 940 | N = 333 | N = 485 | N = 157 | N = 455 | N = 176 | |||||||
HR (95 % CI) | p value | HR (95 % CI) | p value | HR (95 % CI) | p value | HR (95 % CI) | p value | HR (95 % CI) | p value | HR (95 % CI) | p value | |
Age, in yearsa | 1.12 (0.78–1.62) | 0.53 | 0.97 (0.54–1.73) | 0.91 | 1.03 (1.01–1.05) | 0.02 | 1.01 (0.97–1.05) | 0.61 | 0.98 (0.95–1.02) | 0.37 | 1.02 (0.96–1.08) | 0.51 |
Sex (female) | 0.78 (0.55–1.11) | 0.17 | 0.63 (0.35–1.11) | 0.11 | 0.80 (0.49–1.31) | 0.37 | 0.70 (0.31–1.58) | 0.39 | 0.77 (0.46–1.27) | 0.30 | 0.48 (0.20–1.15) | 0.10 |
CCI (0–2) | 1.45 (0.99–2.12) | 0.06 | 1.31 (0.74–2.33) | 0.35 | 1.59 (0.89–2.83) | 0.12 | 1.84 (0.81–4.19) | 0.15 | 1.16 (0.68–1.96) | 0.59 | 0.90 (0.39–2.08) | 0.81 |
Number of medications used (0–5) | ||||||||||||
5–10 | 0.79 (0.53–1.19) | 0.27 | 0.89 (0.47–1.68) | 0.72 | 0.84 (0.45–1.56) | 0.58 | 0.86 (0.35–2.14) | 0.75 | 0.67 (0.39–1.18) | 0.17 | 0.88 (0.35–2.20) | 0.78 |
10–15 | 0.66 (0.34–1.25) | 0.20 | 0.62 (0.25–1.54) | 0.30 | 1.34 (0.50–3.62) | 0.56 | 0.57 (0.13–2.47) | 0.46 | 0.40 (0.17–0.95) | 0.04 | 0.54 (0.16–1.83) | 0.32 |
>15 | 0.63 (0.20–1.97) | 0.42 | 0.87 (0.22–3.50) | 0.85 | 1.35 (0.29–6.20) | 0.70 | 1.28 (0.19–8.63) | 0.80 | 0.22 (0.03–1.76) | 0.15 | 0.48 (0.05–4.56) | 0.52 |
ADL dependency | 2.43 (1.10–5.35) | 0.03 | 7.05 (1.61–30.9) | 0.01 | 1.76 (0.25–12.4) | 0.57 | 1.40 (0.12–16.9) | 0.78 | 3.19 (1.27–8.01) | 0.01 | 10.0 (1.62–62.3) | 0.01 |
Cognitive impairment | 0.54 (0.25–1.17) | 0.12 | 0.26 (0.04–1.57) | 0.14 | 0.74 (0.14–3.91) | 0.72 | – | – | 0.45 (0.18–1.12) | 0.09 | 0.24 (0.03–1.84) | 0.17 |
Living situation (home) | 0.67 (0.29–1.56) | 0.36 | 0.24 (0.04–1.40) | 0.11 | 0.41 (0.03–5.45) | 0.50 | – | – | 0.91 (0.36–2.33) | 0.85 | 0.25 (0.04–1.82) | 0.17 |
AE as reason for the index admission | 1.20 (0.83–1.75) | 0.33 | NA | NA | 1.12 (0.65–1.95) | 0.68 | NA | NA | 1.12 (0.66–1.91) | 0.68 | NA | NA |
Length of stay (linear) | 1.01 (0.99–1.02) | 0.45 | 0.99 (0.96–1.03) | 0.67 | 1.02 (0.99–1.04) | 0.21 | 1.0 (0.94–1.06) | 0.93 | 0.99 (0.96–1.02) | 0.53 | 0.99 (0.95–1.03) | 0.65 |
Season of discharge (summer) | ||||||||||||
Spring | 0.83 (0.52–1.33) | 0.44 | 0.71 (0.32–1.55) | 0.39 | 0.74 (0.37–1.48) | 0.39 | 0.65 (0.21–2.03) | 0.46 | 0.93 (0.48–1.81) | 0.84 | 0.92 (0.29–2.91) | 0.89 |
Autumn | 0.60 (0.36–1.01) | 0.05 | 0.50 (0.22–1.14) | 0.10 | 1.03 (0.52–2.02) | 0.94 | 0.62 (0.20–1.95) | 0.41 | 0.33 (0.14–0.77) | 0.01 | 0.42 (0.12–1.49) | 0.18 |
Winter | 1.10 (0.69–1.76) | 0.69 | 0.84 (0.40–1.77) | 0.66 | 1.12 (0.57–2.19) | 0.75 | 0.86 (0.30–2.46) | 0.78 | 1.01 (0.51–1.98) | 0.98 | 0.82 (0.27–2.51) | 0.83 |
Day of discharge (weekday) | 1.10 (0.71–1.70) | 0.66 | 1.46 (0.77–2.76) | 0.24 | 1.27 (0.71–2.27) | 0.42 | 1.26 (0.52–3.06) | 0.61 | 0.93 (0.47–1.85) | 0.85 | 1.59 (0.62–4.07) | 0.33 |