Prosthetic joint infection development of an evidence-based diagnostic algorithm

Table 7 Value of joint aspiration in the diagnosis of infected total hip arthroplasty

Author	Year	LoE	CoR	(n = x)	Sensitivity	Specificity	Positive predictive value	Negative predictive value	LR for a positive result	LR for a negative result
Barrack et al.	1993	I	I	291
Aspiration culture					0.6 (0.3–0.9)	0.88 (0.84–0.92)	0.15 (0.04–0.27)	0.98 (0.97–1.0)	5.11 (1.91–11.32)	0.45 (0.1–0.83)
Mulcahy et al.	1996	I	I	71
Aspiration culture					0.69 (0.46–0.91)	0.91 (0.83–0.99)	0.69 (0.46–0.91)	0.91 (0.83–0.99)	7.56 (2.76–61.25)	0.34 (0.09–0.65)
Williams et al.	2004	I	I	273
Aspiration culture					0.8 (0.71–0.9)	0.94 (0.9–0.97)	0.81 (0.72–0.91)	0.93 (0.90–0.97)	12.47 (7.23–29.34)	0.21 (0.11–0.32)
Malhotra et al.	2004	I	I	41
Aspiration culture					0.44 (0.12–0.77)	0.91 (0.81–1.0)	0.57 (0.2–0.94)	0.85 (0.73–0.97)	4.74 (0.62–106.19)	0.61 (0.23–1.09)
Schinsky et al.	2008	I	I	201
Wbc (4.2 × 10³)					0.84 (0.74–0.93)	0.93 (0.89–0.97)	0.82 (0.72–0.92)	0.94 (0.90–0.98)	12.21 (6.75–33.94)	0.18 (0.07–0.29)
Neutrophile (80%)					0.82 (0.72–0.92)	0.83 (0.77–0.89)	0.64 (0.53–0.76)	0.92 (0.88–0.97)	4.78 (3.08–8.36)	0.22 (0.09–0.37)
Spanghel et al.	1999	I	I	183
WBC (5.0 × 10³)					0.36 (0.18–0.53)	0.99 (0.98–1.0)	0.91 (0.74–1.0)	0.9 (0.85–0.94)	55.36 (9.43–86.89)	0.65 (0.46–0.84)
Neutrophile (80%)					0.89 (0.78–1.0)	0.85 (079–0.91)	0.52 (0.38–0.66)	0.98 (0.95–1.0)	5.94 (3.76–10.75)	0.13 (0.0–0.28)
Dinneen et al.	2013	I	I	75
WBC (1.58 × 10³)					0.895 (0.783–0.997)	0.913 (0.827–0.999)	n.p.	n.p.	n.p.	n.p.
Neutrophile (65%)					0.897 (0.795–0.999)	0.866 (0.761–0.971)	n.p.	n.p.	n.p.	n.p.

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