Association between estimated glomerular filtration rate and reversion to normoglycemia in people with impaired fasting glucose: a 5-year retrospective cohort study

Table 4 Relationship between eGFR and reversion to normoglycemia in patients with IFG in different models

Exposure	Model I (HR, 95%CI, P)	Model II (HR, 95%CI, P)	Model III (HR, 95%CI, P)	Model IV (HR, 95%CI, P)
eGFR	1.013 (1.011, 1.014) < 0.0001	1.009 (1.008, 1.011) < 0.0001	1.008 (1.006, 1.009) < 0.0001	1.007 (1.006, 1.008) < 0.0001
eGFR (SD)	1.219 (1.195, 1.243) < 0.0001	1.158 (1.135, 1.181) < 0.0001	1.126 (1.102, 1.150) < 0.0001	1.118 (1.094, 1.142) < 0.0001
eGFR Quartile
Q1	Ref.	Ref.	Ref.	Ref.
Q2	1.063 (1.004, 1.125) 0.0353	1.025 (0.969, 1.085) 0.3897	1.011 (0.954, 1.070) 0.7190	1.015 (0.959, 1.075) 0.6066
Q3	1.188 (1.124, 1.255) < 0.0001	1.116 (1.055, 1.180) 0.0001	1.072 (1.013, 1.135) 0.0164	1.070 (1.011, 1.134) 0.0197
Q4	1.619 (1.537, 1.707) < 0.0001	1.423 (1.348, 1.502) < 0.0001	1.314 (1.241, 1.391) < 0.0001	1.295 (1.222, 1.372) < 0.0001
P for trend	< 0.0001	< 0.0001	< 0.0001	< 0.0001

Model I: we did not adjust other covariates
Model II: we adjust BMI, SBP, gender, family history of diabetes, DBP, smoking and drinking status
Model III: we adjust gender, SBP, BMI, FPG, family history of diabetes, DBP, BUN, TG, AST, LDL-c, ALT, HDL-c, smoking and drinking status
Model IV: we adjusted gender, family history of diabetes, BMI (smooth), TG (smooth), DBP (smooth), FPG (smooth), SBP (smooth), BUN (smooth), HDL-c (smooth), ALT (smooth), LDL-c (smooth), AST (smooth), smoking and drinking status
HR Hazard ratios, CI confidence, Ref. reference, eGFR estimated glomerular filtration rate (mL/min·1.73 m²), SD standard deviation

ISSN: 2047-783X