Association between estimated glomerular filtration rate and reversion to normoglycemia in people with impaired fasting glucose: a 5-year retrospective cohort study

Table 8 Stratified associations between eGFR and reversion to normoglycemia in patients with IFG in prespecified and exploratory subgroups

Characteristic	No of participants	HR (95%CI)	P value	P for interaction
Age (years)				0.4975
< 60	18,383	1.005 (1.003, 1.007)	< 0.0001
≥ 60	6158	1.001 (0.999, 1.003)	0.0580
Gender				0.2182
Male	16,265	1.007 (1.005, 1.009)	< 0.0001
Female	8276	1.009 (1.006, 1.011)	< 0.0001
BMI (kg/m²)				0.5534
< 18.5	470	1.006 (0.999, 1.013)	0.1023
≥ 18.5, < 24	9600	1.008 (1.006, 1.010)	< 0.0001
≥ 24, < 28	10,417	1.007 (1.005, 1.009)	< 0.0001
≥ 28	4054	1.005 (1.002, 1.009)	0.0043
Smoking status				0.6506
Never smoker	17,848	1.008 (1.006, 1.009)	< 0.0001
Ever smoker	1074	1.008 (1.001, 1.015)	0.0191
Current smoker	5619	1.006 (1.003, 1.009)	< 0.0001
Drinking status				0.0005
Never drinker	19,952	1.009 (1.007, 1.010)	< 0.0001
Ever drinker	3749	1.001 (0.998, 1.005)	0.4632
Current drinker	840	1.005 (0.997, 1.013)	0.2524
Family history of diabetes				0.2974
No	23,923	1.008 (1.006, 1.009)	< 0.0001
Yes	618	1.002 (0.993, 1.012)	0.6061
SBP (mmHg)				0.2909
< 140	19,347	1.008 (1.006, 1.009)	< 0.0001
≥ 140	5194	1.006 (1.003, 1.009)	< 0.0001
DBP (mmHg)				0.2331
< 90	20,999	1.008 (1.006, 1.009)	< 0.0001
≥ 90	3542	1.005 (1.001, 1.009)	0.0066
TG (mmol/L)				0.9203
< 1.7	15,011	1.008 (1.006, 1.009)	< 0.0001
≥ 1.7	9530	1.007 (1.005, 1.010)	< 0.0001

Note 1: Above model adjusted for SBP, family history of diabetes, BMI, gender, DBP, FPG, TG, ALT, HDL-c, BUN, AST, LDL-c, drinking status, and smoking status
Note 2: In each case, the model is not adjusted for the stratification variable
HR hazard ratios, Ref. reference, CI confidence

ISSN: 2047-783X