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Table 1 Demographic and clinicopathological data of all participants

From: Serum Elabela expression is decreased in hypertensive patients and could be associated with the progression of hypertensive renal damage

 

Healthy control (n = 25)

BHT (n = 25)

MHT (n = 25)

P

Gender (male/female)

19/6

21/4

24/1

0.10

Age (years)

42.48 ± 8.39

40.08 ± 10.43

36.32 ± 11.67

0.12

BMI (kg/m2)

23.07 ± 1.68

29.24 ± 4.80c

26.65 ± 4.40a

<0.01

SBP (mmHg)

118.6 ± 4.7

147.5 ± 9.4c

193.8 ± 19.0a,b

<0.01

DBP (mmHg)

79.88 ± 4.02

92.00 (90.00–100.00)c

114.36 ± 14.33a,b

<0.01

Uric acid

274.84 ± 59.69

503.92 ± 116.81c

508.56 ± 120.21a

<0.01

BUN (mmol/L)

5.17 ± 1.64

7.53 ± 3.10

15.52 (12.15–22.89)a,b

<0.01

Scr (μmol/L)

59.25 ± 11.37

132.00 (103.50–180.50)c

390.00 (237.00–546.50)a,b

<0.01

eGFR (mL/min/1.73 m2)

118.60 ± 22.74

57.67 ± 30.06c

17.00 (8.20–30.00)a,b

<0.01

Elabela (ng/ml)

6.29 ± 0.94

4.73 ± 1.25c

3.82 ± 1.08a,b

<0.01

Histopathological

 TAIF

1.88 ± 0.78

2.63 ± 0.71

<0.01

 Intimal fibrosis

1.00(1.00, 2.00)

2.00(2.00, 2.00)

<0.01

 Fibrinoid necrosis, n (%)

0

9 (62.5)

<0.01

 Myointimal cell proliferation, n (%)

0

22 (91.7)

<0.01

  1. SBP systolic blood pressure, DBP diastolic blood pressure, BUN blood urine nitrogen, Scr serum creatinine, eGFR estimated glomerular filtration rate, TAIF tubular atrophy/interstitial fibrosis.
  2. aP < 0.05, healthy control vs. MHT group; bP < 0.05, BHT group vs. MHT group; cP < 0.05, healthy control vs. BHT group