Fig. 2

Attenuation of cardiac hypertrophy via TOR2A downregulation. a, b The increased cardiomyocyte area induced by Ang II was suppressed after TOR2A downregulation. c–l) The increases of heart weight, HW/BW, HW/TL, LW/BW, LVAWs, LVAWd, LVPWs, LVPWd, IVSs and IVSd in rats infused with Ang II were suppressed after TOR2A downregulation. The increased levels of ANP, BNP and β-MHC in the heart of Ang II-infused rats (m–o) and Ang II-treated NRCMs (p–r) were suppressed by TOR2A downregulation. Data are expressed as the mean ± SEM. a–o Saline +Control shRNA and Saline + TOR2A shRNA groups (n = 7), and Ang II + Control shRNA and Ang II + TOR2A shRNA groups (n = 8). p–r N = 6 in each group. Scale bar: 100 μm. Ang angiotensin, TOR2A torsin family 2 member A, HW heart weight, BW body weight, TL tibia length, LW left ventricle weight, LVAWs left ventricle anterior wall thickness at end systole, LVAWd left ventricle anterior wall thickness at end diastole, LVPWs left ventricle posterior wall thickness at end systole, LVPWd left ventricle posterior wall thickness at end diastole, IVSs interventricular septal thickness at end-systole, IVSd interventricular septal thickness at end-diastole, ANP atrial natriuretic peptide, BNP brain natriuretic peptide, NRCMs neonatal rat cardiomyocytes