Fig. 4

Alleviation of oxidative stress by TOR2A downregulation. The increases of ROS (a) and MDA (b) in the heart of rats infused with Ang II were inhibited by TOR2A downregulation. c The decreased SOD activity in the heart of rats infused with Ang II was reversed after TOR2A downregulation. d, e The increase of ROS production in the heart of rats infused with Ang II was suppressed by TOR2A downregulation. f, g The increase of 8-OHdG positive cells in the heart of rats infused with Ang II was blocked after TOR2A downregulation. Data are expressed as the mean ± SEM. a–c N = 7 in each group. d, g N = 6 in each group. Scale bar: 100 μm. Ang angiotensin, TOR2A torsin family 2 member A, ROS reactive oxygen species, MDA malondialdehyde, SOD superoxide dismutase, 8-OHdG 8-hydroxy-2ʹ-deoxyguanosine