Fig. 1

Distribution of DNA damage repair (DDR) gene mutations in patients with ccRCC. Landscape of DDR genes in the Chinese cohort (A) and TCGA cohort (B). The columns and rows represent patients and genes. Frequency of DDR mutated genes (right), and mutation type for each sample (right). C Significant differences in variant allele frequencies for DDR genes between the Chinese cohort and TCGA cohort. D Distribution of patients with mutations in the 10 DDR functional pathways in both the Chinese cohort and TCGA cohort