Table 2 Univariate and multivariate associations with ΔFEV1 ≥ 400 mL in ACO patients
Variable | Univariate analysis HR (95% Cl) | P-value | Multivariate analysis HR (95% Cl) | P-value |
|---|---|---|---|---|
Age (year) | 0.97 (0.92–1.02) | P = 0.187 | ||
Sex (female vs. male) | 1.40 (0.29–6.81) | P = 0.679 | ||
BMI (kg/m2) | 0.96 (0.81–1.13) | P = 0.598 | ||
Smoking index (pack-year) | 1.00 (0.97–1.02) | P = 0.765 | ||
FEV1 (mL) | 1.71 (0.77–3.78) | P = 0.188 | ||
Predicted FEV1 (%) | 1.01 (0.99–1.03) | P = 0.421 | ||
FVC (mL) | 1.97 (1.04–3.71) | P = 0.037 | 2.71 (1.31–5.63) | P = 0.007 |
Predicted FVC (%) | 1.02 (0.99–1.04) | P = 0.132 | ||
FEV1/FVC (%) | 1.00 (0.96–1.05) | P = 0.982 | ||
FeNO (ppb) | 1.00 (0.99–1.02) | P = 0.519 | ||
Total eosinophils (/μL) | 1.00 (0.99–1.00) | P = 0.543 | ||
Eosinophils (%) | 0.99 (0.72–1.35) | P = 0.937 | 0.06 (0.01–0.55) | P = 0.013 |
ICS/LABA/LAMA (yes vs. no) | 0.12 (0.01–0.94) | P = 0.044 |