Fig. 4

Mitochondrial autophagy of 769-P and Caki-1 was induced by CCCP, which significantly reduced their proliferation, migration and invasion. A CCK-8 experiment showed that increased mitochondrial autophagy inhibited the proliferation of 769-P and Caki-1 cells (**P < 0.01). B The results of cell cloning in vitro showed that the colony formation of renal carcinoma cells with low expression of LBX2-AS1 was inhibited (**P < 0.01). C Cell scratch test results showed that mitochondrial autophagy induced by CCCP in 769-P and Caki-1 decreased cell migration (*P < 0.05, **P < 0.01). D Transwell assay showed that the invasion ability of 769-P and Caki-1 cells could be inhibited after LBX2-AS1 expression was down-regulated (***P < 0.001)