Table 3 Hazard ratios in developing combined liver function (LF) events for the six common liver chemistries with/without introducing time-dependent covariates in the Cox models
Model | Covariate | Value | Hazard ratio (95% CI) | P value |
|---|---|---|---|---|
ALL6 score + covariates | ALL6 score | 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 (cont.) | 1.21 (1.16 – 1.27) |  < 0.001* |
Age |  ≤ 60, > 60–68, > 68–76, > 76 (cont.) | 0.96 (0.83 – 1.11) | 0.583 | |
Gender | Female (Male ref.) | 1.44 (1.01 – 2.06) | 0.046* | |
PVTT/IVCTT | Positive (Negative ref.) | 1.33 (0.93 – 1.91) | 0.114 | |
HBV | Positive (Negative ref.) | 1.03 (0.73 – 1.45) | 0.868 | |
HCV | Positive (Negative ref.) | 1.01 (0.67 – 1.52) | 0.961 | |
CTV | Per 100 mL (cont.) | 0.98 (0.95 – 1.02) | 0.376 | |
NLV | Per 100 mL (cont.) | 1.00 (0.98 – 1.02) | 0.920 | |
NLDmean | Per 1 Gy (cont.) | 0.98 (0.95 – 1.00) | 0.090 | |
ALL6 score + covariates + time-dependent covariates | ALL6 score | 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 (cont.) | 1.17 (1.11 – 1.23) |  < 0.001* |
Age |  ≤ 60, > 60–68, > 68–76, > 76 (cont.) | 0.96 (0.83 – 1.10) | 0.543 | |
Gender | Female (Male ref.) | 1.00 (0.64 – 1.56) | 0.994 | |
PVTT/IVCTT | Positive (Negative ref.) | 1.31 (0.93 – 1.85) | 0.125 | |
HBV | Positive (Negative ref.) | 1.10 (0.79 – 1.54) | 0.560 | |
HCV | Positive (Negative ref.) | 1.04 (0.69 – 1.56) | 0.856 | |
CTV | Per 100 mL (cont.) | 0.98 (0.95 – 1.02) | 0.375 | |
NLV | Per 100 mL (cont.) | 1.00 (0.98 – 1.02) | 0.853 | |
NLDmean | Per 1 Gy (cont.) | 0.98 (0.95 – 1.01) | 0.171 | |
ALL6 score × time | 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 (cont.) per 1 month | 1.00 (1.00 – 1.01) | 0.065 | |
Gender × time | Female (Male ref.) per 1 month | 1.04 (1.01 – 1.07) | 0.006* |