Fig. 3From: The paradoxical role of cytokines and chemokines at the tumor microenvironment: a comprehensive reviewMechanism of cytokine/chemokine activated PI3K/AKT-signaling pathway in tumor growth and replication. The PI3K/AKT pathway is a cellular signaling that leads to cell growth and survival when activated. Interestingly, some cytokines and chemokines have been found to utilize this pathway to promote tumor cell growth and replicationBack to article page