Fig. 4

CD27⁻IFN-γ⁺CD4⁺ (A), CD38⁺IFN-γ⁺CD4⁺ (B) and CD27⁻CD38⁺IFN-γ⁺CD4⁺ (C) on IFN-γ⁺CD4⁺ T cells in peripheral blood stimulated with ESAT-6/CFP-10 in different groups were compared by the Kruskal–Wallis test. CD27⁻IFN-γ⁺CD4⁺ (D), CD38⁺IFN-γ⁺CD4⁺ (E) and CD27⁻CD38⁺IFN-γ⁺CD4⁺ (F) on IFN-γ⁺CD4⁺ T cells in peripheral blood stimulated with ESAT-6/CFP-10 in before and after 2 months or 6 months of TB treatment were compared pair-wise by the Wilcoxon-signed rank paired test. Median values, interquartile range, and P-values below 0.05 are indicated. Receiver operating characteristics (ROC) curves analysis of CD27⁻, CD38⁺, and CD27⁻CD38⁺ on IFN-γ⁺CD4⁺ T cells in peripheral blood stimulated with ESAT-6/CFP-10 comparing before and after 6 months of TB treatment (G). Area under the curve (AUC), 95%CI and P-values are indicated. 0 m Before the TB treatment initiation, 2 m 2 months after TB treatment initiation, 6 m 6 months after TB treatment initiation, LTBI latent tuberculosis infection, HC healthy control