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Table 2 Comparison of serum biomarkers of patients with OSA according to the presence of arteriosclerosis

From: Incremental values of AOPP, IL-6, and GDF15 for identifying arteriosclerosis in patients with obstructive sleep apnea

 

All patient

( n = 104)

OSA without arteriosclerosis

( n = 76)

OSA with arteriosclerosis

( n = 28)

p value

Carotid ultrasound

 PWV_ES (m/s)

5.73 ± 1.25

6.89 ± 1.41

9.43 ± 2.04

0.01

 PWV_BS (m/s)

7.57 ± 1.95

5.34 ± 0.91

6.79 ± 1.42

0.01

Carotid IMT (mm)

0.56 (0.50–0.64)

0.56 (0.52–0.62)

0.57 (0.49–0.68)

0.84

 Sleep characteristics

 AHI (events/h)

54.69 ± 27.12

51.08 ± 26.36

64.51 ± 21.19

0.02

 Mean apnea duration (s)

23.57 ± 8.90

26.32 ± 7.83

28.29 ± 10.96

0.55

 Longest apnea duration (s)

50.40 ± 26.35

66.59 ± 25.30

61.71 ± 17.63

0.18

 Lowest SpO2 (%)

75.65 ± 12.06

70.05 ± 13.80

73.83 ± 14.40

0.43

 Mean SpO2 (%)

92.48 ± 4.54

89.05 ± 6.63

91.07 ± 4.12

0.66

 SIT90 (%)

13.01 ± 17.32

11.97 ± 13.87

13.55 ± 19.00

0.75

 OSA Severity

   

0.45

 Mild–moderate (n/%)

25 (24%)

20 (80%)

5 (20%)

 

 Severe (n/%)

79 (76%)

56 (71%)

23 (29%)

 
  1. Data are presented as mean ± SD or median (interquartile range). Bold value means p < 0.05
  2. PWV_BS pulse wave velocity at the beginning of systole, PWV_ES pulse wave velocity at the end of systole, IMT intima–media thickness, AHI, apnea–hypopnea index, SpO2 blood oxygen saturation, SIT90 ratio of time with SpO2 below 90% in total sleep time