Table 2 The screen results of 30 down-regulated lipid metabolism-associated genes
From: Cortical lipid metabolic pathway alteration of early Alzheimer’s disease and candidate drugs screen
No. | Accession no. | Gene symbol | Gene name | P value | FC (AD/control) |
|---|---|---|---|---|---|
1 | 8082444 | ACAD9 | Acyl-CoA dehydrogenase family member 9 | 0.017 | 0.747 |
2 | ILMN_1671633 | ACOT4 | Acyl-CoA thioesterase 4 | 0.000 | 0.703 |
3 | 7912012 | ACOT7 | Acyl-CoA thioesterase 7 | 0.011 | 0.707 |
4 | 8066598 | ACOT8 | Acyl-coenzyme A thioesterase 8 | 0.002 | 0.747 |
5 | 8174474 | ACSL4 | Long-chain-fatty-acid–CoA ligase 4 | 0.016 | 0.713 |
6 | 8113938 | ACSL6 | Acyl-CoA synthetase long-chain family member 6 | 0.045 | 0.566 |
7 | ILMN_1661596 | ALDH1A1 | Aldehyde dehydrogenase 1 family member A1 | 0.041 | 0.803 |
8 | 8090314 | ALDH1L1 | Aldehyde dehydrogenase 1 family member L1 | 0.045 | 0.736 |
9 | 8117207 | ALDH5A1 | Aldehyde dehydrogenase 5 family member A1 | 0.014 | 0.668 |
10 | 8012309 | ALOX12B | Arachidonate 12-lipoxygenase, 12R type | 0.000 | 0.673 |
11 | 7944418 | C2CD2L | Phospholipid transfer protein C2CD2L | 0.040 | 0.773 |
12 | 7938090 | CKB | Creatine kinase B-type | 0.011 | 0.315 |
13 | 8030448 | CPT1C | Carnitine palmitoyltransferase 1C | 0.018 | 0.618 |
14 | 8164535 | CRAT | Carnitine O-acetyltransferase | 0.026 | 0.781 |
15 | 8127767 | ELOVL4 | Elongation of very long-chain fatty acids protein 4 | 0.032 | 0.425 |
16 | 7914342 | FABP3 | Fatty acid-binding protein 3 | 0.047 | 0.443 |
17 | 8109629 | FABP6 | Fatty acid-binding protein 6 | 0.024 | 0.582 |
18 | 8018251 | FADS6 | Fatty acid desaturase 6 | 0.040 | 0.713 |
19 | 7954631 | FAR2 | Fatty acyl-CoA reductase 2 | 0.025 | 0.444 |
20 | 7943075 | FAT3 | FAT atypical cadherin 3 | 0.022 | 0.446 |
21 | 7929344 | FFAR4 | Free fatty acid receptor 4 | 0.025 | 0.496 |
22 | ILMN_1658548 | HSD17B10 | 3-Hydroxyacyl-CoA dehydrogenase type-2 | 0.001 | 0.808 |
23 | 8020308 | LDLRAD4 | Low-density lipoprotein receptor class A domain containing 4 | 0.036 | 0.828 |
24 | 8085984 | OSBPL10 | Oxysterol-binding protein like 10 | 0.024 | 0.546 |
25 | 7897089 | PLCH2 | Phospholipase C eta 2 | 0.031 | 0.755 |
26 | 8078187 | PLCL2 | Phospholipase C like 2 | 0.012 | 0.470 |
27 | ILMN_1654653 | PLCXD2 | Phosphatidylinositol specific phospholipase C X domain containing 2 | 0.002 | 0.677 |
28 | 8028791 | PLD3 | Phospholipase D family member 3 | 0.012 | 0.595 |
29 | 8025877 | PLPPR2 | Phospholipid phosphatase related 2 | 0.033 | 0.734 |
30 | 7917946 | PLPPR5 | Phospholipid phosphatase related 5 | 0.019 | 0.366 |