Table 3 The screen results of 30 up-regulated lipid metabolism-associated genes
From: Cortical lipid metabolic pathway alteration of early Alzheimer’s disease and candidate drugs screen
No. | Accession no. | Gene symbol | Gene name | P value | FC (AD/control) |
|---|---|---|---|---|---|
1 | 8023261 | ACAA2 | Acetyl-CoA acyltransferase 2 | 0.015 | 1.370 |
2 | ILMN_1671557 | ACACB | Acetyl-CoA carboxylase beta | 0.000 | 1.537 |
3 | 8088397 | ACOX2 | Acyl-CoA oxidase 2 | 0.037 | 1.643 |
4 | 8025011 | ACSBG2 | Acyl-CoA synthetase bubblegum family member 2 | 0.025 | 1.202 |
5 | 8103951 | ACSL1 | Long-chain-fatty-acid–CoA ligase 1 | 0.003 | 1.976 |
6 | ILMN_1651699 | ACSL3 | Long-chain-fatty-acid–CoA ligase 3 | 0.024 | 1.227 |
7 | 8029536 | APOC1 | Apolipoprotein C1 | 0.018 | 2.013 |
8 | ILMN_1671935 | APOC4 | Apolipoprotein C4 | 0.029 | 1.365 |
9 | 8075695 | APOL3 | Apolipoprotein L3 | 0.036 | 1.203 |
10 | 8075709 | APOL4 | Apolipoprotein L4 | 0.047 | 1.763 |
11 | 7954036 | APOLD1 | Apolipoprotein L domain containing 1 | 0.005 | 1.417 |
12 | 7949916 | CHKA | Choline kinase alpha | 0.014 | 1.435 |
13 | 8127145 | ELOVL5 | ELOVL fatty acid elongase 5 | 0.003 | 1.376 |
14 | 7929032 | FAS | Fatty acid synthase | 0.012 | 1.713 |
15 | 8104079 | FAT1 | FAT atypical cadherin 1 | 0.003 | 1.765 |
16 | 8049825 | HDLBP | High-density lipoprotein-binding protein | 0.011 | 1.532 |
17 | 8025828 | LDLR | Low-density lipoprotein receptor | 0.004 | 2.798 |
18 | 7939376 | LDLRAD3 | Low-density lipoprotein receptor class A domain containing 3 | 0.013 | 1.636 |
19 | ILMN_1671500 | OSBPL6 | Oxysterol-binding protein like 6 | 0.000 | 11.834 |
20 | 7908351 | PLA2G4A | Phospholipase A2 group IVA | 0.049 | 1.417 |
21 | 7929388 | PLCE1 | Phospholipase C epsilon 1 | 0.005 | 2.509 |
22 | 8167449 | PLP2 | Proteolipid protein 2 | 0.035 | 1.822 |
23 | 8031999 | PLPP2 | Phospholipid phosphatase 2 | 0.020 | 1.752 |
24 | 7930980 | PLPP4 | Phospholipid phosphatase 4 | 0.039 | 1.815 |
25 | 8091327 | PLSCR1 | Phospholipid scramblase 1 | 0.010 | 2.011 |
26 | 8091306 | PLSCR4 | Phospholipid scramblase 4 | 0.033 | 1.745 |
27 | 8066619 | PLTP | Phospholipid transfer protein | 0.011 | 1.996 |
28 | 7907702 | SOAT1 | Sterol O-acyltransferase 1 | 0.000 | 1.510 |
29 | 7970924 | STARD13 | StAR-related lipid transfer domain containing 13 | 0.030 | 1.290 |
30 | 8053890 | STARD7 | StAR-related lipid transfer domain containing 7 | 0.000 | 1.502 |