Table 4 The GO function classes of 30 down-regulated genes related to lipid metabolism
From: Cortical lipid metabolic pathway alteration of early Alzheimer’s disease and candidate drugs screen
No. | Category | Gene symbol |
|---|---|---|
Molecular function | ||
1 | Binding (GO:0005488) | OSBPL10, ACOT7, FFAR4, ACAD9, LDLRAD4 |
2 | Hydrolase activity (GO:0016787) | ACOT4, ACOT7, PLPPR5, PLPPR2, PLCL2, ACOT8, PLCH2 |
3 | Ligase activity (GO:0016874) | ACSL6, ACSL4 |
4 | Oxidoreductase activity (GO:0016491) | ALDH5A1, ALDH1L1, ACAD9, ALOX12B, FAR2, ALDH1A1 |
5 | Transferase activity (GO:0016740) | CRAT, CKB, CPT1C, ELOVL4 |
6 | Molecular transducer activity (GO:0060089) | FFAR4 |
7 | Transporter activity (GO:0005215) | OSBPL10 |
Biological process | ||
1 | Biological adhesion (GO:0022610) | FAT3 |
2 | Biological regulation (GO:0065007) | FFAR4, PLCL2, PLCH2, LDLRAD4 |
3 | Cellular process (GO:0009987) | FAT3, CRAT, ACOT4, ACOT7, FFAR4, CKB, PLPPR5, CPT1C, ALOX12B, PLPPR2, PLCL2, ACOT8, FAR2, ACSL6, PLCH2, ELOVL4, ACSL4, LDLRAD4 |
4 | Developmental process (GO:0032502) | ACSL4 |
5 | Metabolic process (GO:0008152) | CRAT, ACOT4, ACOT7, CKB, PLPPR5, CPT1C, ALOX12B, PLPPR2, ACOT8, FAR2, ACSL6, ELOVL4, ACSL4, LDLRAD4 |
6 | Multicellular organismal process (GO:0032501) | ACSL4 |
7 | Response to stimulus (GO:0050896) | FFAR4, PLCL2, PLCH2, LDLRAD4 |
8 | Signaling (GO:0023052) | FFAR4, PLCL2, PLCH2, LDLRAD4 |
Cellular component | ||
1 | Cell periphery (GO:0071944) | FFAR4, ACSL6, ELOVL4, ACSL4, LDLRAD4 |
2 | Cell surface (GO:0009986) | FFAR4, ACSL6, ELOVL4, ACSL4, LDLRAD4 |
4 | Cytosol (GO:0005829) | OSBPL10, ACOT7 |
5 | Endomembrane system (GO:0012505) | ACSL6, ELOVL4, ACSL4, LDLRAD4 |
6 | Extracellular region (GO:0005576) | ACOT7 |
7 | Extracellular space (GO:0005615) | ACOT7 |
8 | Intrinsic component of membrane (GO:0031224) | FFAR4, ELOVL4 |
9 | Membrane (GO:0016020) | OSBPL10, FFAR4, ACSL6, ELOVL4, ACSL4, LDLRAD4 |
10 | Membrane-enclosed lumen (GO:0031974) | ACOT7 |
11 | Nucleoplasm (GO:0005654) | ACOT7 |
12 | Organelle (GO:0043226) | CRAT, OSBPL10, ACOT4, ACOT7, ACAD9, CPT1C, FAR2, ACSL6, ELOVL4, ACSL4, LDLRAD4 |
13 | Perinuclear region of cytoplasm (GO:0048471) | ALOX12B |
14 | Cytoplasm (GO:0005737) | CRAT, OSBPL10, ACOT4, ACOT7, ACAD9, CPT1C, ALOX12B, FAR2, ACSL6, ELOVL4, ACSL4, LDLRAD4 |
15 | Intracellular organelle (GO:0043229) | CRAT, OSBPL10, ACOT4, ACOT7, ACAD9, CPT1C, FAR2, ACSL6, ELOVL4, ACSL4, LDLRAD4 |
Protein class | ||
1 | Cell adhesion molecule (PC00069) | FAT3 |
2 | Hydrolase (PC00121) | ACOT4, ACOT7, PLPPR5, PLD3, PLPPR2, PLCL2, ACOT8, PLCH2 |
3 | Ligase (PC00142) | ACSL6, ACSL4 |
4 | Oxidoreductase (PC00176) | HSD17B10, ALDH5A1, ALDH1L1, ACAD9, ALOX12B, ALDH1A1 |
5 | Transferase (PC00220) | CRAT, CKB, CPT1C, ELOVL4 |
6 | Transmembrane signal receptor (PC00197) | FFAR4 |
Pathway | ||
1 | 5-Hydroxytryptamine degradation (P04372) | ALDH1L1, ALDH1A1 |
2 | Gamma-aminobutyric acid synthesis (P04384) | ALDH5A1 |
3 | Histamine H1 receptor mediated signaling pathway (P04385) | PLCL2 |
4 | Wnt signaling pathway (P00057) | FAT3 |