Table 5 The molecular function, biological process, and protein class of 30 up-regulated genes related to lipid metabolism
From: Cortical lipid metabolic pathway alteration of early Alzheimer’s disease and candidate drugs screen
No. | Category | Gene symbol |
|---|---|---|
Protein class | ||
1 | Cell adhesion molecule (PC00069) | FAT1 |
2 | Membrane traffic protein (PC00150) | PLP2 |
3 | Metabolite interconversion enzyme (PC00262) | ACSBG2, SOAT1, ACSL1, ELOVL5, ACSL3, FAS, APOC1, PLA2G4A, PLPP2, ACOX2, PLPP4, ACAA2 |
4 | Nucleic acid metabolism protein (PC00171) | HDLBP |
5 | Protein-binding activity modulator (PC00095) | STARD13 |
6 | Transfer/carrier protein (PC00219) | APOC4, APOC1, LDLRAD3, LDLR, APOL3, APOLD1, APOL4 |
7 | Transporter (PC00227) | PLSCR4, PLSCR1 |
Biological process | ||
1 | Biological adhesion (GO:0022610) | FAT1 |
2 | Biological regulation (GO:0065007) | PLCE1, APOC4, PLSCR4, FAS, APOC1, PLTP, PLSCR1, PLPP2, STARD13, ACOX2 |
3 | Cellular process (GO:0009987) | ACSBG2, SOAT1, ACSL1, ELOVL5, ACSL3, PLCE1, PLSCR4, FAS, APOC1, PLTP, PLA2G4A, PLSCR1, PLPP2, STARD13, FAT1, ACOX2, PLPP4, ACAA2 |
6 | Localization (GO:0051179) | SOAT1, APOC4, PLSCR4, APOC1, PLTP, PLSCR1 |
7 | Metabolic process (GO:0008152) | ACSBG2, SOAT1, ACSL1, ELOVL5, ACSL3, FAS, APOC1, PLA2G4A, PLPP2, ACOX2, PLPP4, ACAA2 |
8 | Multicellular organismal process (GO:0032501) | ACSL3, APOC1, PLTP |
9 | Response to stimulus (GO:0050896) | PLCE1, FAS, PLPP2, STARD13 |