Table 6 The cellular components and pathways classes of 30 up-regulated genes related to lipid metabolism
From: Cortical lipid metabolic pathway alteration of early Alzheimer’s disease and candidate drugs screen
No. | Category | Gene symbol |
|---|---|---|
Molecular function | ||
1 | Binding (GO:0005488) | SOAT1, APOC1, FAS, PLTP, APOL3, APOLD1, PLA2G4A, OSBPL6, HDLBP, ACOX2, APOL4 |
2 | Catalytic activity (GO:0003824) | ACSBG2, SOAT1, ACSL1, ELOVL5, ACSL3, PLCE1, APOC1, PLA2G4A, PLPP2, STARD13, ACOX2, PLPP4, ACAA2 |
3 | Molecular function regulator (GO:0098772) | APOC1, STARD13 |
4 | Transporter activity (GO:0005215) | PLSCR4, PLTP, OSBPL6, PLSCR1 |
Cellular component | ||
1 | Cellular anatomical entity (GO:0110165) | ACSBG2, SOAT1, ACSL1, ELOVL5, ACSL3, PLSCR4, PLTP, APOL3, APOLD1, PLP2, PLA2G4A, OSBPL6, PLSCR1, PLPP2, ACOX2, ACAA2, APOL4 |
2 | Intracellular (GO:0005622) | ACSBG2, SOAT1, ACSL1, ELOVL5, ACSL3, PLA2G4A, OSBPL6, HDLBP, ACOX2, ACAA2 |
3 | Protein-containing complex (GO:0032991) | APOC4, FAS, APOC1, HDLBP |
Pathway | ||
1 | 5HT2 type receptor mediated signaling pathway (P04374) | PLCE1 |
2 | Androgen/estrogen/progesterone biosynthesis (P02727) | SOAT1 |
3 | Apoptosis signaling pathway (P00006) | FAS |
4 | Inflammation mediated by chemokine and cytokine signaling pathway (P00031) | PLA2G4A |
5 | PDGF signaling pathway (P00047) | STARD13 |
6 | Wnt signaling pathway (P00057) | FAT1 |