Cortical lipid metabolic pathway alteration of early Alzheimer’s disease and candidate drugs screen

Table 9 The regulation of candidate drugs to core targets

No.	Chemical name	PubChem ID	ACSL1	ACSBG2	ACAA2	FABP3	ALDH5A1	FFAR4
1	Benzo(a)pyrene	2336	Increases expression	Affects methylation	Affects expression, affects reaction	Affects methylation	Affects methylation and expression	Decreases expression, increases methylation
2	Bisphenol A	6623	Increases expression	Decreases expression, affects methylation	Decreases expression	Affects expression	Increases methylation, affects expression	Decreases expression, increases methylation
3	1,2-Dimethylhydrazine	1322	Decreases expression		Decreases expression	Increases expression	Decreases expression	Decreases expression
4	Ethinyl estradiol	5991	Decreases expression	Affects expression	Decreases expression	Affects expression	Increases expression
5	Pirinixic acid	5694	Increases expression		Increases expression	Increases expression	Increases expression	Increases expression
6	Tetrachlorodibenzodioxin	15625	Decreases expression		Affects expression	Increases expression	Decreases expression	Decreases expression
7	Valproic acid	3121	Increases expression	Affects expression, increases methylation	Decreases methylation, increases expression	Increases expression	Affects expression

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