Fig. 3

Zhenzhu Tongluo pills can significantly improve the physiological indexes and sensory dysfunction in diabetic peripheral neuropathy rats. A Zhenzhu Tongluo pills has no significant improvement effect on blood glucose level in diabetic peripheral neuropathy rats; B Zhenzhu Tongluo pills can improve the decreased body weight gain in diabetic peripheral neuropathy rats (n = 8, ^*p < 0.05, ^**p < 0.01: STZ + PTP (50 mg/kg) vs STZ group; ^#p < 0.05, ^###p < 0.001: STZ + PTP (100 mg/kg) vs STZ group; ^&&&p < 0.001: STZ + PTP (200 mg/kg) vs STZ group; ^$$$p < 0.001: STZ + PTP (400 mg/kg) vs STZ group); C Zhenzhu Tongluo pills significantly improved the mechanical allodynia of diabetic peripheral neuropathy rats (n = 8, ^##p < 0.01: STZ + PTP (100 mg/kg) vs STZ group; ^&p < 0.05, ^&&p < 0.001: STZ + PTP (200 mg/kg) vs STZ group; ^$$p < 0.01, ^$$$p < 0.001: STZ + PTP (400 mg/kg) vs STZ group); D thermal hyperalgesia of diabetic peripheral neuropathy rats was significantly relieved by Zhenzhu Tongluo pills (n = 8; ^&&&p < 0.001: STZ + PTP (200 mg/kg) vs STZ group; ^$$p < 0.01, ^$$$p < 0.001: STZ + PTP (400 mg/kg) vs STZ group)