Fig. 7

Effect of Zhenzhu Tongluo pills on the expression of protein molecules in PI3K–AKT signaling pathway in DRG of diabetic peripheral neuropathy rats. A, B There was no significant change in the expression of total PI3K protein in DRG among all groups (n = 3); A, C Zhenzhu Tongluo pills could significantly improve p-PI3K expression in DRG of diabetic peripheral neuropathy rats (n = 3, ^***p < 0.001 vs Control group; ^#p < 0.05 vs STZ group); A, D There was no significant change in the expression of total AKT in DRG among all groups (n = 3). A, E Zhenzhu Tongluo pills could significantly improve the reduced expression of p-Akt in DRG of diabetic peripheral neuropathy rats (n = 3, ^**p < 0.01 vs Control group; ^#p < 0.05 vs STZ group)