Fig. 8
From: CD133 significance in glioblastoma development: in silico and in vitro study
The effect of CD133 silencing on the signaling factors of the PI3K/Akt and MAPK pathways. A The mRNA expression of RAF1 in different studied groups. CD133 silencing downregulates RAF1 expression in U87MG cells. B The mRNA expression of MAP2K1 in different studied groups. CD133 silencing downregulates MAP2K1 expression in U87MG cells. C The mRNA expression of MAPK3 in different studied groups. CD133 silencing downregulates MAPK3 expression in U87MG cells. D The mRNA expression of PIK3CA in different studied groups. CD133 silencing downregulates PIK3CA expression in U87MG cells. E The mRNA expression of AKT3 in different studied groups. CD133 silencing downregulates AKT3 expression in U87MG cells. F The mRNA expression of mTOR in different studied groups. CD133 silencing downregulates mTOR expression in U87MG cells. **P-value ≤ 0.01, ***P-value ≤ 0.001, and ****P-value ≤ 0.0001