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Table 1 Baseline characteristics of the patients

From: Predicting sepsis in-hospital mortality with machine learning: a multi-center study using clinical and inflammatory biomarkers

 

Survivors

Non-survivors

P value

 

N = 2980

N = 555

 

Age, years

65.(0 55.0–76.0)

72.0 (62.1–80.0)

< 0.001

Gender

  

0.260

 F

1326 (44.5%)

232 (41.8%)

 

 M

1654 (55.5%)

323 (58.2%)

 

White blood cells, × 103/µL

13.6 (10.1–18.4)

14.7 (10.6–20.0)

0.001

Lymphocytes

1.45 (0.90–2.31)

1.26 (0.79–2.12)

0.001

Neutrophils

10.9 (7.44–15.2)

11.9 (7.85–16.9)

0.002

Monocytes

0.93 (0.59–1.42)

0.94 (0.55–1.42)

0.588

Platelet

225 (169–296)

214 (154–282)

0.004

Triglycerides, mg/dL

106 (74.0–157)

104 (77.0–147)

0.757

Total cholesterol, mg/dL

128 (99.0–164)

114 (88.9–150)

< 0.001

High-density lipoprotein, mg/dL

35.0 (25.0–47.0)

32.0 (21.5–44.0)

< 0.001

Hemoglobin, g/dL

12.6 (10.9–14.3)

12.4 (10.3–14.0)

0.011

Albumin, g/dL

3.20 (2.70–3.70)

3.00 (2.40–3.50)

< 0.001

Bun, mg/dL

25.0 (16.2–40.0)

34.0 (20.9–51.0)

< 0.001

Calcium, mg/dL

8.70 (8.20–9.20)

8.70 (8.10–9.20)

0.025

Creatinine, mg/dL

1.25 (0.90–2.00)

1.70 (1.10–2.60)

< 0.001

Glucose, mg/dL

171 (133–229)

187 (143–247)

< 0.001

Sodium, mmol/L

140 (138–143)

141 (138–146)

< 0.001

Potassium, mmol/L

4.40 (4.10–4.90)

4.60 (4.20–5.20)

< 0.001

ALT, IU/L

30.0 (19.0–55.2)

38.0 (21.0–97.0)

< 0.001

AST, IU/L

36.0 (23.0–76.0)

60.0 (32.0–200)

< 0.001

PH

7.41 (7.36–7.46)

7.40 (7.35–7.46)

0.091

Heart rate

106 (92.0–122)

113 (96.0–129)

< 0.001

Systolic blood pressure

155 (136–176)

155 (134–178)

0.898

Diastolic blood pressure

90.0 (77.0–105)

91.0 (76.0–105)

0.631

Mean blood pressure

162 (137–187)

160 (134–186)

0.306

Respiratory rate

28.0 (24.0–35.0)

30.0 (25.0–37.0)

0.001

Temperature

37.4 (37.0–38.0)

37.3 (36.9–37.9)

0.072

First day sofa score

6.00 (4.00–9.00)

9.00 (7.00–12.0)

< 0.001

Length of hospital stays

38.0 (14.0–86.0)

36.0 (8.00–118)

0.605

Renal replacement therapy

  

< 0.001

 No

2732 (91.7%)

448 (80.7%)

 

 Yes

248 (8.32%)

107 (19.3%)

 

Invasive ventilation

  

< 0.001

 No

1197 (40.2%)

116 (20.9%)

 

 Yes

1783 (59.8%)

439 (79.1%)

 

Myocardial infarct

  

0.293

 No

2648 (88.9%)

484 (87.2%)

 

 Yes

332 (11.1%)

71 (12.8%)

 

Congestive heart failure

  

0.838

 No

2409 (80.8%)

446 (80.4%)

 

 Yes

571 (19.2%)

109 (19.6%)

 

Peripheral vascular disease

  

0.566

 No

2834 (95.1%)

524 (94.4%)

 

 Yes

146 (4.90%)

31 (5.59%)

 

Dementia

  

0.835

 No

2831 (95.0%)

529 (95.3%)

 

 Yes

149 (5.00%)

26 (4.68%)

 

Chronic pulmonary disease

  

0.465

 No

2533 (85.0%)

479 (86.3%)

 

 Yes

447 (15.0%)

76 (13.7%)

 

Peptic ulcer disease

  

0.612

 No

2933 (98.4%)

544 (98.0%)

 

 Yes

47 (1.58%)

11 (1.98%)

 

Renal disease:

  

0.003

 No

2508 (84.2%)

438 (78.9%)

 

 Yes

472 (15.8%)

117 (21.1%)

 

diabetes:

  

0.003

 No

2009 (67.4%)

410 (73.9%)

 

 Yes

971 (32.6%)

145 (26.1%)

 

Liver disease:

  

0.015

 No

2876 (96.5%)

523 (94.2%)

 

 Yes

104 (3.49%)

32 (5.77%)

 

Cerebrovascular disease:

  

0.010

 No

2509 (84.2%)

442 (79.6%)

 

 Yes

471 (15.8%)

113 (20.4%)

 

LMR

1.63 (1.00–2.56)

1.42 (0.94–2.48)

0.018

NLR

7.16 (4.18–12.0)

8.71 (4.90–14.7)

< 0.001

PLR

152 (94.5–238)

151 (90.5–269)

0.436

MHR

0.03 (0.02–0.05)

0.03 (0.01–0.05)

0.204

NHR

0.31 (0.19–0.50)

0.35 (0.21–0.64)

< 0.001

  1. LMR: the ratio of lymphocytes to monocytes; NLR: the ratio of neutrophils to lymphocytes; PLR: the ratio of platelets to lymphocytes; MHR: the ratio of monocytes to high-density lipoprotein; NHR: the ratio of neutrophils to high-density lipoprotein