Table 2 Diagnostic accuracy of biomarkers
Biomarker | Specificity | Sensitivity | Positive like hood ratio | Negative like hood ratio | AUC | Heterogeneity of sensitivity | Heterogeneity of specificity | Heterogeneity of Positive like hood ratio | Heterogeneity of Negative like hood ratio | Q |
|---|---|---|---|---|---|---|---|---|---|---|
Cystatin-C | 0.81 (0.79–0.82) | 0.74 (0.69–0.79) | 4.35 (2.85- 6.65) | 0.25 (0.13–0.50) | 0.89 | 88.7%, P < 0.01 | 96.4%, P < 0.01 | 93.7%, P < 0.01 | 90.3%, P < 0.01 | 0.82 |
BNP | 0.73 (0.71–0.75) | 0.72 (0.67–0.77) | 2.85 (2.13–3.82) | 0.39 (0.28–0.53) | 0.80 | 56.1%, P = 0.01 | 94.0%, P < 0.01 | 89.1%, P < 0.01 | 70.6%, P < 0.01 | 0.73 |
uKIM-1 | 0.76 (0.73–0.79) | 0.84 (0.78–0.88) | 3.58 (2.75–4.66) | 0.25 (0.17–0.37) | 0.85 | 42.4%, P = 0.08 | 64.0%, P < 0.01 | 51.1% P = 0.03 | 20.3% P = 0.26 | 0.78 |
NGAL | 0.85 (0.83–0.86) | 0.78 (0.73–0.83) | 6.02 (3.86–9.40) | 0.26 (0.17–0.41) | 0.91 | 73.1%, P < 0.01 | 91.6%, P < 0.01 | 85.0%, P < 0.01 | 65.5%, P < 0.01 | 0.84 |