Table 1 Summary of the mechanism of natural compounds
Natural compounds | Function | Reference |
|---|---|---|
Berberine | Inhibits iron toxicity by reducing ROS production and lipid peroxidation in iron-treated cardiac cells | [168] |
Resveratrol | Reduce oxidative stress and attenuating ferroptosis | [172] |
Baicalin | Regulate ferroptosis by inhibiting ACSL4 | [176] |
Cyanidin-3-O-glucoside | Upregulate FTH1 and GPX4 expression | [181] |
Naringenin | Activates the Nrf2/SLC7A11/GPX4 axis by upregulating Nrf2, SLC7A11, GPX4, FTH1, and ferroportin-1, and downregulating NOX1 NADPH oxidase to inhibit ferroptosis | [184] |
Gossypol acetic acid | Decrease ACSL4 and Nrf2 protein levels, and upregulate GPX4 protein levels | [187] |
Astragaloside IV | Activate the Nrf2/GPX4 pathway to alleviate myocardial ferroptosis induced by DOX | [192] |
Ophiopogonin D | Regulate ferroptosis, thereby protect myocardial cells | [196] |
Artesunate | Inhibit the PERK/ATF4/CHOP pathway activation | [200] |
Luteolin | Enhance Nrf2 nuclear transcription and activate the Nrf2/Gpx4 pathway | [204] |
Puerarin | Alleviate ferroptosis | [210] |
Schizandrin B | Activate the Nrf2/HO-1/GPX4 signaling pathway | [216] |
Salvianolic acid B | Upregulate the expression and phosphorylation of Cx43 protein | [221] |
Apigenin | Activate the AMPK/Nrf2/HO-1 signaling pathway | [226] |
Thymoquinone | Activate the Nrf2/HO-1 signaling pathway | [229] |