Fig. 3

Different expression of ion channel subtypes in colorectal cancer. A Gene Ontology enrichment analysis of DEGs was conducted. B A Heatmap was used to display the expression of 88 survival-related DEGs in the TCGA CRC dataset. The gene clusters and common clinical variables were used as patient annotations. C Three distinct Gene clusters were identified by the principal component analysis of 985 DEGs in the TCGA CRC dataset. D Significant differences were shown in the survival curve for gene subtypes (log-rank test, p = 0.0026). E Alluvial diagram exhibited the association of ion channel subtypes, gene subtypes, and survival states. F A total of 19 prognosis-related ion channel DEGs were expressed among the Gene clusters. (Kruskal–Wallis test, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001). DEGs differentially expressed genes, TCGA The Cancer Genome Atlas, CRC colorectal cancer