Fig. 2

GO, KEGG enrichment analysis and GSEA of DEGs. A Differentially expressed genes were presented using volcano plot. GO enrichment analysis of DEGs for B biological processes, C cellular components and D molecular functions. E KEGG pathway enrichment analysis of DEGs. F GSEA of DEGs. DEGs differentially expressed genes, ECM extracellular matrix, GO Gene Ontology, GSEA Gene Set Enrichment Analysis, KEGG Kyoto Encyclopedia of Genes and Genomes, MET metformin, P. adj adjusted P-value, PTK protein tyrosine kinase