Fig. 3

Association between immune cells infiltration and FNDC3B expression in the tumor microenvironment. A The association between FNDC3B expression and immune cells abundance in pan-cancer via TIMER online tool. B The correlation between FNDC3B expression and immune cells abundance via ssGSEA. (C–F) Comparison of the abundances of C T helper cells, D Th2 cells, E pDCs and F Th17 cells between FNDC3B-low and -high groups. G–J Scatter plots presented the association between the abundances in G T helper cells, H Th2 cells, I pDCs and J Th17 cells and FNDC3B expression levels. K–M The ESTIMATE related scores built based on TCGA database. *P < 0.05; **P < 0.01; ***P < 0.001 and ****P < 0.0001. DC dendritic cells, iDC immature dendritic cells, FNDC3B fibronectin type III domain containing 3B, NK natural killer, pDC plasmacytoid dendritic cells, Tcm central memory T cells, TFH T follicular helper cells, TGD γδT cells, Th T helper, TPM transcripts per million, Treg regulatory T cells