Table 1 Demographic characteristics and comorbidities in the propensity-score-matched cohorts with and without colchicine used among patients with the immune-mediated inflammatory diseases
Variable | Not matched | p-value | Propensity score matched | p-value | ||
|---|---|---|---|---|---|---|
Colchicine | Colchicine | |||||
No | Yes | No | Yes | |||
N = 76,224 | N = 22,464 | N = 16,026 | N = 16,026 | |||
Age, year | < 0.001 | 0.06 | ||||
≤ 49 | 37,581 (49.3) | 8818 (39.3) | 6073 (37.9) | 6279 (39.2) | ||
50–64 | 24,818 (32.6) | 7828 (34.9) | 6009 (37.5) | 5870 (36.6) | ||
65+ | 13,825 (18.1) | 5818 (25.9) | 3944 (24.6) | 3877 (24.2) | ||
Median ± (IQR)a | 50.3 (38.5–60.8) | 54.0 (43.8–65.4) | 53.7 (43.7–64.6) | 54.3 (44.1–64.8) | ||
Sex | < 0.001 | 0.001* | ||||
Female | 44,370 (58.2) | 7884 (35.1) | 7700 (48.1) | 7138 (44.5) | ||
Male | 31,854 (41.8) | 14,580 (64.9) | 8326 (52.0) | 8888 (55.5) | ||
Comorbidities | ||||||
Alcohol-related illness | 30,956 (40.6) | 11,856 (52.8) | < 0.001 | 8364 (52.2) | 8550 (53.4) | 0.04* |
CAD | 1860 (2.44) | 1136 (5.06) | < 0.001 | 575 (3.59) | 597 (3.73) | 0.51 |
Diabetes | 11,059 (14.5) | 4860 (21.6) | < 0.001 | 3138 (19.6) | 3285 (20.5) | 0.04* |
Hypertension | 40,059 (52.6) | 16,264 (72.4) | < 0.001 | 10,965 (68.4) | 11,157 (69.6) | 0.02* |
Hyperlipidemia | 49,968 (65.6) | 18,081 (80.5) | < 0.001 | 12,942 (80.8) | 12,784 (79.8) | 0.03* |
COPD | 5366 (7.04) | 3872 (17.2) | < 0.001 | 2020 (12.6) | 2016 (12.6) | 0.95 |
Stroke | 5878 (7.71) | 2795 (12.4) | < 0.001 | 1731 (10.8) | 1684 (10.5) | 0.39 |
Depression | 10,193 (13.4) | 15,754 (70.1) | < 0.001 | 9318 (58.1) | 9316 (58.1) | 0.98 |
Tobacco use | 5878 (7.71) | 2795 (12.4) | < 0.001 | 1856 (11.6) | 1874 (11.7) | 0.75 |
Chronic kidney disease | 5258 (6.90) | 2365 (10.5) | < 0.001 | 1544 (9.63) | 1517 (9.47) | 0.61 |
Charlson comorbidity index ≧1 | 26,500 (34.6) | 11,400 (50.6) | < 0.001 | 7600 (47.4) | 7578 (47.2) | 0.96 |
Medications | ||||||
Acetylcysteine | 7914 (10.4) | 3034 (13.5) | < 0.001 | 2066 (12.9) | 2045 (12.8) | 0.73 |
Smoking cessation-related | 3611 (4.74) | 1598 (7.11) | < 0.001 | 982 (6.13) | 938 (5.85) | 0.30 |
Anti-inflammatory and immunosuppressant drugs | 34,654 (45.5) | 14,619 (65.1) | < 0.001 | 9192 (57.4) | 9691 (60.5) | 0.01* |