Table 4 Incidence and hazards ratio of colorectal cancer measured by age, sex, comorbidities and medications in the propensity score-matched cohorts by Cox proportional hazard models with time-dependent exposure covariates among the immune-mediated inflammatory diseases
Variables | Propensity score matched | ||||
|---|---|---|---|---|---|
Colchicine | Adjusted HRb (95% CI) | ||||
No (N = 16,026) | Yes (N = 16,026) | ||||
Event | Ratea | Event | Ratea | ||
Colorectal cancer | |||||
Age, years | |||||
≤ 49 | 22 | 0.43 | 9 | 0.17 | 0.27(0.12,0.83)** |
50–64 | 82 | 1.78 | 18 | 0.47 | 0.79(0.40, 0.59)** |
65+ | 66 | 2.49 | 12 | 0.75 | 0.88(0.36, 3.49) |
Sex | |||||
Female | 71 | 1.15 | 23 | 0.56 | 0.47(0.31, 0.66)** |
Male | 99 | 1.60 | 16 | 0.79 | 0.61(0.55, 0.89)* |