Table 3 GRADE assessment
No. of studies | Study design | Risk of bias | Certainty assessment | Vagueness | Other considerations | No. of patients | Effect | Certainty | Importance | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Inconsistency | Indirect evidence | Protocolized sedation | Usual care | Relative (95% CI) | Absolute (95% CI) | |||||||
Mortality | ||||||||||||
10 | Randomized trials | Serious | Not serious | Not serious | Not serious | None | 260/1037 (25.1%) | 335/1058 (31.7%) | OR 0.80 (0.70 to 0.92) | 46 less per 1000 (from 72 to 18 less) | ⨁⨁⨁◯ Moderate | CRITICAL |
Ventilation days | ||||||||||||
8 | Randomized trials | Serious | Not serious | Not serious | Not serious | None | 820 | 816 | – | MD 1.12 days less (2.11 less to 0.14 less) | ⨁⨁⨁◯ Moderate | IMPORTANT |
Length of days in ICU | ||||||||||||
10 | Randomized trials | Serious | Not serious | Not serious | Not serious | None | 1038 | 1058 | – | MD 2.3 days less (3.58 less to 1.02 less) | ⨁⨁⨁◯ Moderate | IMPORTANT |
Self-extubation | ||||||||||||
7 | Randomized trials | Serious | Very serious | Not serious | Very serious | None | 26/609 (4.3%) | 17/608 (2.8%) | OR 1.20 (0.49 to 2.94) | 5 more for 1000 (from 14 less to 50 more) | ⨁◯◯◯ Very low | IMPORTANT |