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Table 3 Severity and outcomes of patients with COVID-19 categorized according to primary series dose of vaccine

From: Influence of vaccination on critical COVID-19 patients with acute respiratory failure: a retrospective cohort study

 

Primary series (− ) (n = 91)

Primary series ( +) (n = 29)

Booster doses (n = 93)

p-value

Severity

 PaO2/FiO2 ratio

141 (82–135)

140 (105–234)

139 (84–250)

0.747

 SOFA

8 (6–11)

10 (5–12)

8 (6–11)

0.560

 APACHEII

23 (19–28)

24 (18–32)

25 (17–29)

0.883

 ARDS

60 (64.5)

21 (72.4)

66 (71.0)

0.563

Life support

 Mechanical ventilation

53 (57.0)

20 (69.0)

58 (62.4)

0.479

 Newly renal replacement therapy

8 (8.6)

2(6.9)

11 (11.8)

0.650

 ECMO

2 (2.2)

3 (10.3)

3 (3.2)

0.119

 Initial vasopressors use

31 (33.3)

8 (27.6)

31 (33.3)

0.828

Outcomes

 Hospital days

30 (14–45)

23 (13–43)

25 (16–39)

0.737

 28-day ventilator-free days

0 (0–19)

7 (0–16)

10 (0–18)

0.879

 In hospital mortality

41 (44.1)

11 (37.9)

43 (46.2)

0.734

 28-day mortality

29 (31.2)

7 (24.1)

30 (32.3)

0.704

 Time from symptoms onset to 1st Ct > 30, days

11 (6–17)

12 (6–18)

9 (1–18)

0.675

  1. Primary series (− ): not completing the primary vaccine series (0 or 1 dose). Primary series ( +): completing the primary vaccine series (2 doses). Booster doses: receiving the booster vaccine (3 or more doses). Continuous data are expressed as median with IQR, and categorical data are expressed as number of patients (%). P-value is analyzed by Chi-square test, one way ANOVA or Kruskal–Wallis H test. Data are presented as median (IQR) and n(%) unless otherwise indicated. N/A not applicable
  2. SOFA Sequential Organ Failure Assessment, APACHE II Acute Physiology and Chronic Health Evaluation, ARDS acute respiratory distress syndrome, ECMO extracorporeal membrane Oxygenation