Time course of serum heparan sulfate concentrations after administration of endotoxin (T0). Endotoxin group: #: p < 0.001 for T2 versus T0; p < 0.001 for T2 versus T1. Comparison between groups: $: p < 0.001 for T2. T0: Baseline, immediately before endotoxin administration; T1: 3 h after endotoxin administration; T2: 6 h after endotoxin administration. Values are mean ± SD.