Measurement of lidocaine half-life before and after initiation of therapy in HIV-patients with various anti-viral regimens: A. Lidocaine half-life - expressed in minutes - was significantly lower in HIV-patients without ART. * p < 0.05, n = patients' number. B. Lidocaine half-life - measured 3 and 6 months (mo.) after initiation of ART - was almost identical with no obvious changes under antiretroviral treatment in patients with HIV-infection. C. Hepatitis C co-infection in HIV-patients had no significant influence on lidocaine half-life and activity of cytochrome p450.