Co-medication | Effect of co-medication on raltegravir AUC | Reference |
---|---|---|
NRTIs | Â | Â |
   • Tenofovir | +49% | [28] |
NNRTIs | Â | Â |
   • Efavirenz | -36% | [16] |
   • Etravirine | -34% | [23] |
PIs | Â | Â |
   • Tipranavir/r | -24% | [18] |
   • Ritonavir (low-dose) | -16% | [16] |
   • Atazanavir (400 mg QD) | +72% | [15] |
   • Atazanavir (300 mg BD) | +53% | [17] |
   • Atazanavir/r | +41% | [15] |
   • Darunavir/r | -29% | [19] |
   • Lopinavir/r | +3% | [20] |
Other agents | Â | Â |
   • Rifampin (RAL 400 mg BD) | -40% | [26] |
   • Rifampin (RAL 800 mg BD) | +27% | [26] |
   • Omeprazole | +221% | [27] |