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Table 1 Hepatic grade 3/4 laboratory abnormalities in ART naïve patients on Raltegravir or Efavirenz, both in combination with TDF/FTC.

From: HIV/HCV-coinfection: which role can new antiretrovirals such as integrase inhibitors play?

Adverse Event Toxicity Criteria Grade 3 or 4 Raltegravir n = 281 Efavirenz n = 282
Total bilirubin > 2.5 × ULN 2 (0.7) 0 (0.0)
Alkaline phosphatase > 5 × ULN 0 (0.0) 2 (0.8)
AST > 5 × ULN 6 (2.1) 5 (1.8)
ALT > 5 × ULN 5 (1.8) 6 (2.1)
  1. AST aspartate amino transferase; AP alkaline phosphatase; ALT alanine aminotransferase; ULN upper limit of normal