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Table 1 Amino-acid substitutions observed in viruses escaping RAL treatment (from Sichtig et al., J Antimicrob Ther 2009).

From: HIV resistance to raltegravir

Primary (pathway-specific) mutations

N155H, Q148R/H/K, Y143R/C

Secondary mutations

L74M, E92Q, T97A, Y143H, V151I, G163R, E138A/K, G140S/A

Occasional mutations/polymorphisms

H51Y, T66I, V72I, L74A/I, S119R/G/P/T, T112I, F121Y, T125A/K, A128T, Q146K, S147G, S153Y/A, M154I, K156N, E157Q, K160D, V165I, V201I, I203M, T206S, S230R/N, V249I, R263K, C280Y