| | | |
F/ICS
|
F/ICS/Th
|
|---|
|
FKBP51
|
Protein
|
Cytosol (C)
|
100.0 ± 18.1
|
157.6 ± 21.4**
|
| | |
Nuclei (N)
|
61.0 ± 11.9
|
79.5 ± 14.7*
|
| | |
Ratio (C/N)
|
1.64 ± 0.36
|
1.98 ± 0.38**
|
| |
mRNA
|
100.0 ± 46.8
|
132.7 ± 51.1
| |
- Relative content of cytosolic and nuclear FKBP51 protein and FKBP51 mRNA in cells isolated from induced sputum of stable COPD patients treated with formoterol + budesonide (F/ICS; n = 18) and formoterol + budesonide + theophylline (F/ICS/Th; n = 18) b.i.d. for 4 wk. Expressions of FKBP51 were equalized in each sample for loading and numerized with density software. The mean FKBP51 expression in cytosolic fraction of cells isolated from F/ICS-treated patients was set as 100 relative units. *P < 0.05 compared with the F/ICS-treated group; **P < 0.01 compared with the F/ICS-treated group.
