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Table 1 Tumor marker concentration in pleural fluid (P), serum (S), and the P/S ratio (R) in patients with malignant vs.

From: Diagnostic utility of pleural fluid and serum markers in differentiation between malignant and non-malignant pleural effusions

  Malignant effusion (n = 36) Non-malignant effusion (n = 38) P
CA-125(P) 965.9 (412.9-1790.5) 518.5 (297.7-796.6) NS
CEA(P) 12.1 (1.9-79.2) 1.1 (0.8-1.6) < 0.001
CYFRA 21-1(P) 27.5 (14.8-213.6) 12.8 (5.0-31.5) < 0.05
NSE(P) 2.7 (0.9-10.5) 1.0 (0.2-4.3) < 0.05
CA-125(S) 180.7 (68.4-404.8) 135.8 (60.6-191.4) NS
CEA(S) 4.1 (1.7-28.1) 2.3 (1.5-3.4) < 0.05
CYFRA 21-1(S) 4.6 (2.1-16.6) 1.9 (1.2-2.7) < 0.001
NSE(S) 15.8 (10.9-30.5) 11.9 (8.1-18.4) NS
CA-125(R) 4.6 (2.6-7.1) 3.7 (2.6-6.9) NS
CEA(R) 1.4 (0.8-3.9) 0.5 (0.4-0.7) < 0.001
CYFRA 21-1(R) 0.1 (0.06-0.8) 0.1 (0.02-0.3) NS
NSE(R) 6.9 (2.1-11.1) 6.9 (2.6-20.5) NS
  1. nonmalignant PE.
  2. Values are presented as median (with IQR in parenthesis). CA-125 (mU/ml), CEA (μg/ml), CYFRA 21-1 (ng/ml), and NSE (ng/ml).