Table 2 Receiver operating characteristics (ROC) for the four tumor markers with their cut-off points for achieving the best diagnostic accuracy.
Cut-off | Sensitivity % (95% CI) | Specificity % (95% CI) | PPV % (95% CI) | NPV % (95% CI) | Accuracy AUC | |
|---|---|---|---|---|---|---|
CA-125(P) | 1017 | 50.0 (32.9-67.1) | 81.6 (65.7-92.4) | 72.0 (50.6-87.9) | 63.3 (48.3-76.6) | 0.64 |
CEA(P) | 2.71 | 72.2 (54.8-85.8) | 92.1 (78.6-98.3) | 89.7 (72.2-97.9) | 77.8 (62.9-88.8) | 0.83 |
CYFRA21-1(P) | 74.7 | 41.7 (25.5-59.2) | 92.1 (78.6-98.3) | 83.3 (57.7-96.6) | 62.5 (48.5-75.1) | 0.69 |
NSE(P) | 0.22 | 94.4 (81.1-99.3) | 36.1 (20.8-53.8) | 59.6 (45.8-72.4) | 86.7 (59.5-98.3) | 0.65 |
CA-125(S) | 214.2 | 44.4 (27.9-61.9) | 78.9 (62.7-90.4) | 66.7 (44.7-84.4) | 60.0 (45.2-73.6) | 0.6 |
CEA(S) | 3.27 | 61.1 (43.5-76.9) | 73.7 (54.1-84.6) | 68.7 (50.0-83.9) | 66.7 (50.5-80.4) | 0.65 |
CYFRA 21-1(S) | 2.42 | 72.2 (54.8-85.8) | 73.7 (56.9-86.6) | 72.2 (54.8-85.8) | 73.7 (56.9-86.6) | 0.78 |
NSE(S) | 10.6 | 80.6 (64.0-91.8) | 47.4 (31.0-64.2) | 59.2 (44.2-73.0) | 72.0 (50.6-87.9) | 0.62 |
CA-125(R) | 11.16 | 22.2 (10.1-39.2) | 94.7 (82.3-99.4) | 80.0 (44.4-97.5) | 56.2 (43.3-68.6) | 0.54 |
CEA(R) | 0.83 | 69.4 (51.9-83.7) | 89.5 (75.2-97.1) | 86.2 (68.3-96.1) | 75.6 (60.5-87.1) | 0.84 |
CYFRA 21-1(R) | 11.4 | 77.8 (60.8-89.9) | 42.1 (26.3-59.2) | 56.0 (41.3-70) | 66.7 (44.7-84.4) | 0.54 |
NSE(R) | 0.04 | 83.3 (67.2-93.6) | 44.7 (28.6-61.7) | 58.8 (44.2-72.4) | 73.9 (51.0-90.1) | 0.62 |