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Table 2 Receiver operating characteristics (ROC) for the four tumor markers with their cut-off points for achieving the best diagnostic accuracy.

From: Diagnostic utility of pleural fluid and serum markers in differentiation between malignant and non-malignant pleural effusions

  Cut-off Sensitivity % (95% CI) Specificity % (95% CI) PPV % (95% CI) NPV % (95% CI) Accuracy AUC
CA-125(P) 1017 50.0 (32.9-67.1) 81.6 (65.7-92.4) 72.0 (50.6-87.9) 63.3 (48.3-76.6) 0.64
CEA(P) 2.71 72.2 (54.8-85.8) 92.1 (78.6-98.3) 89.7 (72.2-97.9) 77.8 (62.9-88.8) 0.83
CYFRA21-1(P) 74.7 41.7 (25.5-59.2) 92.1 (78.6-98.3) 83.3 (57.7-96.6) 62.5 (48.5-75.1) 0.69
NSE(P) 0.22 94.4 (81.1-99.3) 36.1 (20.8-53.8) 59.6 (45.8-72.4) 86.7 (59.5-98.3) 0.65
CA-125(S) 214.2 44.4 (27.9-61.9) 78.9 (62.7-90.4) 66.7 (44.7-84.4) 60.0 (45.2-73.6) 0.6
CEA(S) 3.27 61.1 (43.5-76.9) 73.7 (54.1-84.6) 68.7 (50.0-83.9) 66.7 (50.5-80.4) 0.65
CYFRA 21-1(S) 2.42 72.2 (54.8-85.8) 73.7 (56.9-86.6) 72.2 (54.8-85.8) 73.7 (56.9-86.6) 0.78
NSE(S) 10.6 80.6 (64.0-91.8) 47.4 (31.0-64.2) 59.2 (44.2-73.0) 72.0 (50.6-87.9) 0.62
CA-125(R) 11.16 22.2 (10.1-39.2) 94.7 (82.3-99.4) 80.0 (44.4-97.5) 56.2 (43.3-68.6) 0.54
CEA(R) 0.83 69.4 (51.9-83.7) 89.5 (75.2-97.1) 86.2 (68.3-96.1) 75.6 (60.5-87.1) 0.84
CYFRA 21-1(R) 11.4 77.8 (60.8-89.9) 42.1 (26.3-59.2) 56.0 (41.3-70) 66.7 (44.7-84.4) 0.54
NSE(R) 0.04 83.3 (67.2-93.6) 44.7 (28.6-61.7) 58.8 (44.2-72.4) 73.9 (51.0-90.1) 0.62
  1. P - Pleural fluid values, S - Serum values, R - Ratio between pleural fluid and serum.
  2. PPV - Positive Predictive Value; NPV - Negative Predictive Value.