Table 4 Case-control analysis of ADAM33 F+1 allele frequencies and genotype distributions (genotypes in comparison with controls)
From: ADAM33 gene polymorphisms in chronic obstructive pulmonary disease
All COPD | Stable COPD | Unstable COPD | Control | |
|---|---|---|---|---|
Homozygotes for wild type | 53 (35.3%) | 24 (40.0%) | 29 (32.2%) | 61 (40.1%) |
Heterozygotes for mutation | 73 (48.7%) | 30 (50.0%) | 43 (47.8%) | 74 (48.7%) |
Homozygotes for mutation | 24 (16.0%) | 6 (10.0%) | 18 (20.0%) | 17 (11.2%) |
Carrier frequency of the mutant allele | 40.3% (121/300) | 35.0% (42/120) | 43.9% (79/180) | 35.5% (180/304) |
P-value (Armitage's trend test) | 0.22 | 0.92 | 0.07 |