Skip to main content

Table 3 Association of the N363S (p = 0.878), BCLI (p = 0.343), ER2223EK (p = 0.966) and disease severity.

From: Glucocorticoid receptor gene polymorphisms and potential association to chronic obstructive pulmonary disease susceptibility and severity

GOLD

 

Wild-type

Heterozygote

Homozygote

N363S Polymorphism- n (%)

Chronic bronchitis

23

21 (91.3)

2 (8.7)

0 (0.0)

GOLD I

8 7

(87.5)

1 (12.5)

0 (0.0)

GOLD II

66

58 (87.9)

8 (12.1)

0 (0.0)

GOLD III

50

45 (90.0)

5 (10.0)

0 (0.0)

GOLD IV

60

54 (90.0)

6 (10.0)

0 (0.0)

BCLI Polymorphism- n (%)

chronic bronchitis

23

9 (39.1)

11 (47.8)

3 (13.0)

GOLD I

8

1 (12.5)

5 (62.5)

2 (25.1)

GOLD II

66

24 (36.4)

31 (47.0)

11 (16.7)

GOLD III

50

21 (42.0)

20 (40.0)

9 (18.0)

GOLD IV

60

28 (46.7)

25 (41.7)

7 (11.7)

ER2223EK Polymorphism- n (%)

chronic bronchitis

23

23 (100)

0 (0.0)

0 (0.0)

GOLD I

8

7 (87.5)

1 (12.5)

0 (0.0)

GOLD II

66

63 (95.5)

3 (4.6)

0 (0.0)

GOLD III

50

47 (94.0)

3 (6.0)

0 (0.0)

GOLD IV

60

58 (96.7)

2 (3.3)

0 (0.0)

  1. No significant differences were observed between GOLD stages and those single nucleotide polymormphisms (SNPs).