Table 1 Problems in aerosol therapy and their solution (modified according to [4, 6, 13, 24]).
Source of the problem | Type of the problem | Solution of the problem |
|---|---|---|
Device | Low aerosol output | Vibrating mesh nebulizers |
Aerosol distribution width | Dry powder inhalers (DPI) | |
Variability of aerosol particle spectrum | Metered dose inhalers (MDI) | |
Long treatment times for drug solutions | Vibrating mesh nebulizers | |
Compound | Formulation: | Optimisation of manufacturing: |
Chemical/physical stability | Refinement of production processes | |
Aerodynamic diameter | Addition of stabilising excipients | |
Adhesion force | ||
Electrical charge | ||
Biology: | Improvement of galenics: | |
Permeability | Addition of absorption enhancers and | |
Metabolism | proteinase inhibitors and packing into | |
Safety | particles | |
Immunogenicity |