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Table 1 Patient characteristics

From: Bendamustine in patients with relapsed or refractory multiple myeloma

   Subgroups therapy mode   Subgroups dosage  
  Total Monotherapy + Steroids p 80-100 mg/m 2 120-150 mg/m 2 p
Age 61 (41-83) 61 (41-83) 61 (47-68) 0.4 63 (41-76) 61 (42-83) 0.7
Sex        
male 15 (38%) 8 (67%) 16 (59%) 0.7 13 (62%) 11 (61%) 1
female 24 (62%) 4 (33%) 11 (41%) 0.7 8 (38%) 7 (39%) 1
Myeloma subtype        
IgG 35 (90%) 11 (92%) 24 (89%) 1 20 (95%) 15 (83%) 0.3
Other 4 (10%) 1 (8%) 3 (11%) 1 1 (5%) 3 (17%) 0.3
ISS stage        
I 16 (41%) 1 (8%) 15 (56%) 0.01 9 (43%) 7 (38%) 1
II 11 (28%) 6 (50%) 5 (19%) 0.1 6 (29%) 5 (28%) 1
III 7 (18%) 3 (25%) 4 (15%) 0.7 4 (19%) 3 (17%) 1
   Not available 5 (13%) 2 (17%) 3 (11%) 0.6 2 (9%) 3 (17%) 0.6
Salmon & Durie stage        
I 2 (5%) 2 (17%) 0 (0%) 0.1 1 (5%) 1 (6%) 1
II 7 (18%) 0 (0%) 7 (26%) 0.1 2 (10%) 5 (28%) 0.2
III 30 (77%) 10 (83%) 20 (74%) 0.7 18 (86%) 12 (67%) 0.3
Metaphase cytogenetics        
Normal 26 (67%) 8 (67%) 18 (67%) 1 15 (71%) 11 (61%) 0.5
Abnormal 7 (18%) 2 (17%) 5 (19%) 1 4 (19%) 3 (17%) 1
Not done 6 (15%) 2 (17%) 4 (15%) 1 2 (10%) 4 (22%) 0.4
Osteolytic lesions 29 (84%) 9 (75%) 20 (74%) 1 17 (81%) 12 (67%) 0.5
Extramed. Disease 11 (28%) 3 (25%) 8 (30%) 1 6 (29%) 5 (28%) 1
Previous Therapy        
   Refractory disease 22 (56%) 7 (58%) 15 (56%) 1 11 (52%) 11 (61%) 0.8
   Relapsed disease 17 (44%) 5 (42%) 12 (44%) 1 10 (48%) 7 (38%) 0.8
Prior lines of therapy 2 (1-5) 2 (1-5) 2 (1-5) 1 2 (1-5) 2 (1-5) 1
   Prior radiotherapy 27 (69%) 9 (75%) 18 (67%) 0.7 15 (71%) 12 (67%) 1
   Prior thalidomide 23 (59%) 5 (42%) 18 (67%) 0.2 11 (52%) 12 (67%) 0.5
   Prior HDT 25 (64%) 5 (42%) 20 (74%) 0.1 11 (52%) 14 (78%) 0.2
   Prior 2nd salvage HDT 9 (23%) 2 (17%) 4 (15%) 1 2 (10%) 4 (22%) 0.4
β2-microglobulin [mg/l] 3.0 (1.3-8.4) 4.8 (2.2-7.7) 2.6 (1.3-8.4) 0.2 2.7 (1.7-7.7) 3.4 (1.3-8.4) 0.9
LDH [U/l] 178 (95-988) 244 (137-536) 174 (95-988) 0.6 185 (114-613) 172 (95-988) 0.8
Calcium [mmol/l] 2.6 (1.9-3.1) 2.46 (2.1-2.5) 2.3 (1.9-3.1) 0.5 2.3 (2.0-2.5) 2.6 (1.9-3.1) 1.0
CRP [mg/l] 0.8 (0.1-14.2) 1 (0.1-3.1) 0.8 (0.1-14.2) 0.5 0.8 (0.1-11.3) 0.8 (0.1-14.2) 0.8
Haemoglobine level [g/l] 11.5 (7.4-17.4) 11.4 (7.9-14.4) 12.2(7.4-17.4) 0.3 11.6 (7.9-14.4) 11.4 (7.4 - 14.3) 0.8
Platelet counts [× 1.000/μl] 148 (20-455) 161 (20-319) 140 (38-455) 0.8 140 (20-319) 168 (38-455) 0.1
Creatinine [mg/ml] 0,9 (0,4-5,2) 1,2 (04,-5,2) 0,9 (0,4-1,6) 0,2 0,9 (0,4-1,5) 1,0 (0,4-5,2) 0,5