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Table 1 Patient characteristics

From: Bendamustine in patients with relapsed or refractory multiple myeloma

  

Subgroups therapy mode

 

Subgroups dosage

 
 

Total

Monotherapy

+ Steroids

p

80-100 mg/m 2

120-150 mg/m 2

p

Age

61 (41-83)

61 (41-83)

61 (47-68)

0.4

63 (41-76)

61 (42-83)

0.7

Sex

       

male

15 (38%)

8 (67%)

16 (59%)

0.7

13 (62%)

11 (61%)

1

female

24 (62%)

4 (33%)

11 (41%)

0.7

8 (38%)

7 (39%)

1

Myeloma subtype

       

IgG

35 (90%)

11 (92%)

24 (89%)

1

20 (95%)

15 (83%)

0.3

Other

4 (10%)

1 (8%)

3 (11%)

1

1 (5%)

3 (17%)

0.3

ISS stage

       

I

16 (41%)

1 (8%)

15 (56%)

0.01

9 (43%)

7 (38%)

1

II

11 (28%)

6 (50%)

5 (19%)

0.1

6 (29%)

5 (28%)

1

III

7 (18%)

3 (25%)

4 (15%)

0.7

4 (19%)

3 (17%)

1

   Not available

5 (13%)

2 (17%)

3 (11%)

0.6

2 (9%)

3 (17%)

0.6

Salmon & Durie stage

       

I

2 (5%)

2 (17%)

0 (0%)

0.1

1 (5%)

1 (6%)

1

II

7 (18%)

0 (0%)

7 (26%)

0.1

2 (10%)

5 (28%)

0.2

III

30 (77%)

10 (83%)

20 (74%)

0.7

18 (86%)

12 (67%)

0.3

Metaphase cytogenetics

       

Normal

26 (67%)

8 (67%)

18 (67%)

1

15 (71%)

11 (61%)

0.5

Abnormal

7 (18%)

2 (17%)

5 (19%)

1

4 (19%)

3 (17%)

1

Not done

6 (15%)

2 (17%)

4 (15%)

1

2 (10%)

4 (22%)

0.4

Osteolytic lesions

29 (84%)

9 (75%)

20 (74%)

1

17 (81%)

12 (67%)

0.5

Extramed. Disease

11 (28%)

3 (25%)

8 (30%)

1

6 (29%)

5 (28%)

1

Previous Therapy

       

   Refractory disease

22 (56%)

7 (58%)

15 (56%)

1

11 (52%)

11 (61%)

0.8

   Relapsed disease

17 (44%)

5 (42%)

12 (44%)

1

10 (48%)

7 (38%)

0.8

Prior lines of therapy

2 (1-5)

2 (1-5)

2 (1-5)

1

2 (1-5)

2 (1-5)

1

   Prior radiotherapy

27 (69%)

9 (75%)

18 (67%)

0.7

15 (71%)

12 (67%)

1

   Prior thalidomide

23 (59%)

5 (42%)

18 (67%)

0.2

11 (52%)

12 (67%)

0.5

   Prior HDT

25 (64%)

5 (42%)

20 (74%)

0.1

11 (52%)

14 (78%)

0.2

   Prior 2nd salvage HDT

9 (23%)

2 (17%)

4 (15%)

1

2 (10%)

4 (22%)

0.4

β2-microglobulin [mg/l]

3.0 (1.3-8.4)

4.8 (2.2-7.7)

2.6 (1.3-8.4)

0.2

2.7 (1.7-7.7)

3.4 (1.3-8.4)

0.9

LDH [U/l]

178 (95-988)

244 (137-536)

174 (95-988)

0.6

185 (114-613)

172 (95-988)

0.8

Calcium [mmol/l]

2.6 (1.9-3.1)

2.46 (2.1-2.5)

2.3 (1.9-3.1)

0.5

2.3 (2.0-2.5)

2.6 (1.9-3.1)

1.0

CRP [mg/l]

0.8 (0.1-14.2)

1 (0.1-3.1)

0.8 (0.1-14.2)

0.5

0.8 (0.1-11.3)

0.8 (0.1-14.2)

0.8

Haemoglobine level [g/l]

11.5 (7.4-17.4)

11.4 (7.9-14.4)

12.2(7.4-17.4)

0.3

11.6 (7.9-14.4)

11.4 (7.4 - 14.3)

0.8

Platelet counts [× 1.000/μl]

148 (20-455)

161 (20-319)

140 (38-455)

0.8

140 (20-319)

168 (38-455)

0.1

Creatinine [mg/ml]

0,9 (0,4-5,2)

1,2 (04,-5,2)

0,9 (0,4-1,6)

0,2

0,9 (0,4-1,5)

1,0 (0,4-5,2)

0,5