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Table 4 Association of selected C-terminal mutations with N-terminal resistance-associated mutations (*)

From: Mutations in the C-terminal region of the HIV-1 reverse transcriptase and their correlation with drug resistance associated mutations and antiviral treatment

Position according to) HXB2 (*2

Association of C-terminal mutations with TAMs [p = ]

Association of C-terminal mutations with NAMs [p = ]

Association of C-terminal mutations with NNRTI-resistance-delivering mutations [p = ]

358

0.095

0.608

0.113

369

0.014

0.008

0.579

395

0.002

0.043

0.112

399

< 0.001

0.003

0.205

431

0.139

0.675

0.024

451

0.031

0.409

0.056

468

0.088

0.192

0.585

469

0.103

1

0.014

470

0.761

0.500

0.094

483

1

0.562

0.086

491

0.416

0.561

0.013

509

0.033

0.657

0.062

520

0.097

0.002

0.482

524

0.719

0.044

1

  1. *Only the p-values of mutations that are either statistical associated or showing the tendency to be associated to N-terminal resistance-associated mutations are shown
  2. *2 All replacements that occurred at the indicated sites were included in the statistic analysis