The table shows the amino acid alignment of ubiquitin and ubiquitin-like proteins. The boxes with the number 1 - 7 have identical amino acid sequences. The ribbed boxes have similar amino acid sequences (= conservative replacement).
All Sentrine family members have distinct N-terminal amino acid sequences and C-terminal extensions. The Gly-Gly residues required for sentrine conjugation are conserved in all sentrine family members. The sequences of all the sentrins are identical in human, mouse and rat, in keeping with the high degree of conservation of ubiquitin in mammalian cells.