Shows the reaction to GuttaFlow and AHPlus. A-C shows the tissue reaction to AHPlus; A) shows a well vascularised (double head arrows) granulation tissue. HE, 200 × magnification. B) and C) emphasize the collagen matrix component within this granulation tissue and the active absorption of the biomaterial by macrophages (arrows). (B = Movat's Pentachrome-staining, 400 × magnification); (C = Azan-staining, 400 × magnification). D-F shows the tissue reaction to GuttaFlow. D) shows GuttaFlow which was surrounded by a thin cell rich and poorly vascularised capsule, HE-staining, 40 × magnification. E) and F) demonstrate that no GuttaFlow particle was incorporated by the tissue which surrounded the biomaterial. (E = Azan-staining, 200 × magnification); (F = HE-staining, 400 × magnification).